Publications

2024

W. van Bergen, K. Zuna, J. Fiala, E. E. Pohl, A. J. R. Heck, M. P. Baggelaar, Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs. ACS Chemical Biology, 2024

C. A. Ocasio, M. P. Baggelaar, J. Sipthorp, A. Losada de la Lastra, M. Tavares, J. Volarić, C. Soudy, E. M. Storck, J. W. Houghton, S. A. Palma-Duran, J. I. MacRae, G. Tomić, L. Carr, J. Downward, U. Eggert, E. W. Tate, A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature Biotechnology, 2024, 9087
G. Tomić, C. Sheridan, A. Y. Refermat, M. P. Baggelaar, J. Sipthorp, B. Sudarshan, C. A. Ocasio, A. Suárez-Bonnet, S. L. Priestnall, E. Herbert, E. W. Tate, J. Downward, Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis. Cell Reports, 2024, 43(5), 114224.

2023

S. Sardana, E. E. Nederstigt, M.P. Baggelaar, S-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells, J. Proteome Res, 2023

W. van Bergen, J. Hevler, W. Wu, M.P. Baggelaar, A.J.R. Heck, Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Molecular & Cellular Proteomics, 2023, 22

2022

W. van Bergen, A.J.R. Heck, M. P. Baggelaar, Recent advancements in mass spectrometry–based tools to investigate newly synthesized proteins, Current Opinion in Chemical Biology, 2021, 66, 102

2019

Zhou J., Mock E.D., Martella A., Kantae V., Di X., Burggraaff L., Baggelaar M.P., Al-Ayed K., Bakker A., Florea B.I., Grimm S.H., den Dulk H., Li C.T., Mulder L., Overkleeft H.S., Hankemeier T.., van Westen G.J.P., van der Stelt M. Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI ACS Chem. Biol. 2019, 14, 164-16
Baggelaar M.P.#, den Dulk H., Florea B.I., Fazio D., Bernabò N., Raspa M., Janssen A.P.A., Scavizzi F., Barboni B., Overkleeft H.S., Maccarrone M., van der Stelt M. # ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction. ACS Chem. Biol. doi: 10.1021/acschembio.9b00640. [Epub ahead of print].

2018

van Rooden E.J., van Esbroeck A.C.M., Baggelaar M.P., Deng H., Florea B.I., Marques A.R.A., Ottenhoff R., Boot R.G., Overkleeft H.S., Aerts J.M.F.G., van der Stelt M. Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain Front. Neurosci. 2018, 2, 440
Baggelaar M.P., Maccarrone M., van der Stelt M.. 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain Prog. Lipid Res. 2018, 71, 1-17.
van Rooden E.J., Florea B.I., Deng H., Baggelaar M.P., van Esbroeck A.C.M., Zhou J., Overkleeft H.S., van der Stelt M. Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification Nat. Protoc. 2018, 13, 752-767

2017

Petracca R., Romeo E., Baggelaar M.P., Artola M., Pontis S., Ponzano S., Overkleeft H.S., van der Stelt M., Piomelli D. Novel activity-based probes for N-acylethanolamine acid amidase Chem. Commun. (Camb) 2017, 53, 11810-11813
van Esbroeck A.C.M., Janssen A.P.A., Cognetta A.B. 3rd, Ogasawara D., Shpak G., van der Kroeg M., Kantae V., Baggelaar M.P., de Vrij F.M.S., Deng H., Allarà M., Fezza F., Lin Z., van der Wel T., Soethoudt M., Mock E.D., den Dulk H., Baak I.L., Florea B.I., Hendriks G., De Petrocellis L., Overkleeft H.S., Hankemeier T., De Zeeuw C.I., Di Marzo V., Maccarrone M., Cravatt B.F., Kushner S.A., van der Stelt M. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 Science 2017, 356, 1084-1087. IF: ‎41.04 (S)
Deng H., van der Wel T., van den Berg R.J.B.H.N., van den Nieuwendijk A.M.C.H., Janssen F.J., Baggelaar M.P., Overkleeft H.S., van der Stelt M. Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors Medchemcomm. 2017, 8, 982-988
Soethoudt M., Grether U., Fingerle J., Grim T.W., Fezza F., de Petrocellis L., Ullmer C., Rothenhäusler B., Perret C., van Gils N., Finlay D., MacDonald C., Chicca A., Gens M.D., Stuart J., de Vries H., Mastrangelo N., Xia L., Alachouzos G., Baggelaar M.P., Martella A., Mock E.D., Deng H., Heitman L.H., Connor M., Di Marzo V., Gertsch J., Lichtman A.H., Maccarrone M., Pacher P., Glass M., van der Stelt M. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity Nat. Commun. 2017, 8, 13958
Deng H., Kooijman S., van den Nieuwendijk A.M., Ogasawara D., van der Wel T., van Dalen F., Baggelaar M.P., Janssen F.J., van den Berg R.J., den Dulk H., Cravatt B.F., Overkleeft H.S., Rensen P.C., van der Stelt M. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding J. Med. Chem. 2017, 60, 428-440
Baggelaar MP, van Esbroeck AC, van Rooden EJ, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M. # Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases ACS Chem. Biol. 2017, 12, 852-861.

2016

Ogasawara D., Deng H., Viader A., Baggelaar M.P., Breman A., den Dulk H., van den Nieuwendijk A.M., Soethoudt M., van der Wel T., Zhou J., Overkleeft H.S., Sanchez-Alavez M., Mo S., Nguyen W., Conti B., Liu X., Chen Y., Liu Q.S., Cravatt B.F., van der Stelt M. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc. Natl. Acad. Sci. U S A 2016, 113, 26-33
Mukhopadhyay P, Baggelaar M.P., Erdelyi K, Cao Z, Cinar R, Fezza F, Ignatowska-Janlowska B, Wilkerson J, van Gils N, Hansen T, Ruben M, Soethoudt M, Heitman L, Kunos G, Maccarrone M, Lichtman A, Pacher P, Van der Stelt M. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. Br. J. Pharmacol. 2016, 173, 446-58

2015

Baggelaar M.P., Chameau P.J., Kantae V., Hummel J., Hsu K.L., Janssen F., van der Wel T., Soethoudt M., Deng H., den Dulk H., Allarà M., Florea B.I., Di Marzo V., Wadman W.J., Kruse C.G., Overkleeft H.S., Hankemeier T., Werkman T.R., Cravatt B.F., van der Stelt M. # Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. J. Am. Chem. Soc. 2015, 137, 8851-7.
Janssen FJ, Baggelaar M.P., Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M. Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. J. Med. Chem. 2015, 58, 9742-53
Ouairy CM, Ferraz MJ, Boot RG, Baggelaar M.P., van der Stelt M, Appelman M, van der Marel GA, Florea BI, Aerts JM, Overkleeft HS. Development of an acid ceramidase activity-based probe. Chem. Commun. (Camb). 2015, 51, 6161-3
van der Wel T, Janssen FJ, Baggelaar M.P., Deng H, den Dulk H, Overkleeft HS, van der Stelt M. A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α. J. Lipid Res. 2015, 56, 927-35

2014

Janssen FJ, Deng H, Baggelaar M.P., Allarà M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. J. Med. Chem. 2014, 57, 6610-22

2013

Baggelaar M.P., Janssen F.J., van Esbroeck A.C., den Dulk H., Allarà M., Hoogendoorn S., McGuire R., Florea B.I., Meeuwenoord N., van den Elst H., van der Marel G.A., Brouwer J., Di Marzo V., Overkleeft H.S., van der Stelt M. # Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. Angew. Chem. Int. Ed. Engl. 2013, 52, 12081-5
Baggelaar M.P., Huang Y., Feringa B.L., Dekker F.J., Minnaard A.J. Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor. Bioorg. Med. Chem. 2013, 21, 5271-4.

2012

Barroso S, Castelli R, Baggelaar M.P., Geerdink D, ter Horst B, Casas-Arce E, Overkleeft HS, van der Marel GA, Codée JD, Minnaard AJ. Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis. Angew. Chem. Int. Ed. Engl. 2012, 51, 11774-7

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